Genome editing is a set of techniques for introducing targeted changes in genomes.It may be achieved by enzymes collectively called site-directed nucleases (SDN).Site-specificity of SDNs is provided either by the DNA binding domain of the protein molecule itself or by RNA molecule(s) that direct SDN to a specific site in the genome.In contrast to t
Abstract.The authors present the case of Training Course a patient who developed an Aspergillosis flavus (A flavus) superficial cutaneous infection which was identified at the time of cast removal, 2 weeks after immobilization of a closed distal third humerus fracture.Clinical and microbiological findings, as well as the treatment of this patient,
Abstract Background Neoadjuvant therapy improves recurrence-free survival (RFS) in resectable stage III cutaneous melanoma.However, accurately predicting individual recurrence risk remains a significant challenge.We investigated circulating tumour DNA (ctDNA) as a biomarker for recurrence in measurable stage IIIB/C melanoma patients undergoing neoa
Ensemble local mean decomposition has been gradually introduced into mechanical vibration signal processing due to its excellent performance in electroencephalogram signal analysis.However, an unsatisfactory problem is that ensemble local mean decomposition cannot effectively process vibration signals of complex mechanical system due to the constra
The ovary is a dynamic organ where mechanical forces profoundly regulate follicular development, oocyte maturation, and overall reproductive function.These forces, originating from the extracellular matrix (ECM), granulosa and theca cells, and ovarian stroma, influence cellular behavior through mechanotransduction, translating mechanical stimuli in